I haven’t encountered any ads that won’t eventually let me out, if I wait long enough.
There is a Chill Pill ad that says it will let me get the reward early, but doesn’t. I have to watch the whole thing before the close box actually works.
I hate to be the bearer of bad news, but not only is it very unlikely that you get your reward, but you might even lose some unsaved progress if the ad actually freezes the game.
I suggest manually saving (in the settings screen) before watching the ads, just to be safe.
Also, it would be good to take a screenshot of the ad that’s causing you problems and post that picture here. That way the developers can contact the ad provider and get it removed/fixed.
P.S. You are not the first to experience this. The sooner they know which ad it is, the sooner it will be fixed.